2025/08/08 by Muhammad Imran Qadir, Munaza Gillani · 1 voice
Neuroscience · #Hearing, Cochlea, Tinnitus, Genetics #Vestibular and auditory disorders #Hearing Loss and Rehabilitation
paper · pdf · doi:10.70389/pjg.100004
openalex publication_date 2025/08/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/16
Hearing is one of the major senses that enables distant communication, with the cochlea in the inner ear and its associated structures serving as the site where sound waves are transformed into an action potentials. However, this processing of hearing is disrupted by many factors, which include infectious agents, cardiovascular disease, diabetes mellitus, and advancing age (age-related hearing loss [ARHL]). ARHL or presbycusis is the most common communication disorder, which is primarily the degeneration of the cochlea. It is a complicated and multifactorial disease exacerbated by both genetic background and environment of an individual. The affected individuals are unable to hear and recognize the sound especially in noisy areas. Four categories of hearing loss have been represented. Many genes and quantitative trait loci control the trait of hearing. Many studies have been conducted on a mouse model for studying the effects of different loci on hearing loss. The problem of hearing loss may cause incident dementia, fall, depression, and social isolation in the affected individuals. However, an early assessment could help to curtail the negative outcome of hearing impairment. Use of hearing aids is effective in perceiving sound, thus, helpful in hearing. However, they are not easily affordable for many individuals. The aim of the study was to evaluate different types of hearing loss: ARHL, its genetic, cellular, and molecular basis, and its evaluation and treatment.