Strain background effects and genetic modifiers of hearing in mice

2006/04/01 by Kenneth R. Johnson, Qing Yin Zheng, Konrad Noben-Trauth +1 · 27 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · Nursing · #Hearing, Cochlea, Tinnitus, Genetics #Genetic Mapping and Diversity in Plants and Animals #Biochemical Analysis and Sensing Techniques

paper · doi:10.1016/j.brainres.2006.02.021

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• Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. [europepmc]
• Genetic dependence of cochlear cells and structures injured by noise. [europepmc]
• A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice. [europepmc]
• Mutation profile of the CDH23 gene in 56 probands with Usher syndrome type I. [europepmc]
• Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. [europepmc]
• Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis. [europepmc]
• Wild-derived mouse stocks: an underappreciated tool for aging research. [europepmc]
• PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. [europepmc]
• A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. [europepmc]
• The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. [europepmc]
• Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. [europepmc]
• Association of a citrate synthase missense mutation with age-related hearing loss in A/J mice. [europepmc]
• Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. [europepmc]
• A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing function. [europepmc]
• Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice. [europepmc]
• Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair. [europepmc]
• Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice. [europepmc]
• The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice. [europepmc]
• Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review. [europepmc]
• Helios is a key transcriptional regulator of outer hair cell maturation. [europepmc]
• Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice. [europepmc]
• Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. [europepmc]
• Clarin-2 is essential for hearing by maintaining stereocilia integrity and function. [europepmc]
• Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss. [europepmc]
• A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. [europepmc]