Oxidation-responsive PEG-poly(α-lipoic acid) nanoparticles for coenzyme Q 10 delivery attenuate hepatic ischemia-reperfusion injury via ROS scavenging and ferroptosis inhibition

2025/01/01 by Yu Guan, Jinyu Liu, Jing Yang +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemical effects in animals #Coenzyme Q10 studies and effects #Liver Disease and Transplantation

paper · doi:10.1039/d5tb01118c

openalex publication_date 2025/01/01 · openalex created_date 2025/06/06 · openalex updated_date 2026/08/01

Abstract

nanoparticle is a novel antioxidant nanomedicine that synergistically attenuates ROS-mediated damage and ferroptotic cell death in hepatic IRI. These findings highlight a promising strategy for protecting organs from ischemia-reperfusion damage by targeting oxidative stress and ferroptosis with responsive biomaterial carriers.

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