A Mechanistic Understanding of Reactive Oxygen Species (ROS)‐Responsive Bio‐Polymeric Nanoparticles: Current State, Challenges and Future Toward Precision Therapeutics

2025/05/01 by Vivek Pandey, Tejasvi Pandey · 22 citations
Chemistry · Engineering · Materials Science · #Advanced Nanomaterials in Catalysis #Biochemistry #Biology #Cell biology #Chemistry #Drug #Drug delivery #Drug discovery #Immunology #Inflammation #Materials science #Nanoparticle-Based Drug Delivery #Nanoplatforms for cancer theranostics #Nanotechnology #Pharmacology #Reactive oxygen species

paper · doi:10.1002/bip.70027

published in Biopolymers 116(3), e70027 (Wiley)

openalex publication_date 2025/05/01 · openalex created_date 2025/05/15 · openalex updated_date 2026/07/23

Abstract

Inflammation is a hallmark of various pathological conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases. Reactive oxygen species (ROS) are crucial mediators in the inflammatory microenvironment, playing a pivotal role in both normal cellular processes and disease progression. Targeting ROS overproduction in inflamed tissues has emerged as a promising therapeutic strategy. Polymeric nanoparticles (NPs) responsive to ROS levels in pathological tissues have gained substantial attention as precision drug delivery systems, capable of ensuring controlled, site-specific drug release. This review provides a comprehensive mechanistic insight into ROS-responsive polymeric nanoparticles, examining their structural design, functionalization strategies, drug release mechanisms, and potential for targeted therapies in inflammatory conditions. Furthermore, we discuss recent advancements, challenges, and future directions in utilizing ROS-responsive polymeric nanoparticles for precision therapeutics, highlighting their transformative potential in clinical applications.

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