Autologous extracellular vesicles derived from conjunctival squamous cell carcinoma deliver therapeutic microRNAs to induce apoptosis in originating cancer

2025/01/01 by Suresh Thangudu, Sourabh Mehta, Hala Shakib Dhowre +5 · 1 voice
Biochemistry, Genetics and Molecular Biology · Engineering · #Extracellular vesicles in disease #MicroRNA in disease regulation #Nanoplatforms for cancer theranostics

paper · doi:10.1039/d5tb00587f

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

H&E staining. Taken together, we show that targeted delivery of therapeutic miRNAs encapsulated within autologously-derived EVs may have substantial potential in future adjunctive clinical treatment for cSCC. This novel approach may provide a minimally invasive and personalized strategy that could be combined with topical chemotherapy in future clinical applications.

Citations

• Surgical Management of Conjunctival Tumors
• Extracellular vesicles as drug delivery systems: Why and how?
• RNA delivery by extracellular vesicles in mammalian cells and its applications
• Drug delivery systems for RNA therapeutics

Discussions

• Issue 34 for @JMaterChem B is available now! Front cover: "Autologous extracellular vesicles derived from conjunctival squamous cell carcinoma deliver therapeutic microRNAs to induce apoptosis in orig [bsky, 0 points, 0 comments]