Nickel-catalysed sequential hydrodefluorination of pyridines: mechanistic insights led to the discovery of bench-stable precatalysts

2025/01/01 by Victor Duran Arroyo, Roger Nuñez, Rebeca Arévalo · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic C–H Functionalization Methods #Fluorine in Organic Chemistry #Inorganic Fluorides and Related Compounds

paper · doi:10.1039/d5qi01257k

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/22

Abstract

The nickel(0) complex [Ni( iPr PN)(COD)] ( iPr PN = 2-[( N -diisopropylphosphino)methylamino]pyridine, COD = 1,5-cyclooctadiene) was an efficient precatalyst for the hydrodefluorination of partially fluorinated pyridines employing pinacolborane (HBPin).

Citations

• Contribution of Organofluorine Compounds to Pharmaceuticals
• Deuterium in drug discovery: progress, opportunities and challenges

Discussions

• Inside cover of Issue 18 presents Nickel-catalysed sequential hydrodefluorination of pyridines: mechanistic insights led to the discovery of bench-stable precatalysts by Rebeca Arevalo 𝘦𝘵 𝘢𝘭. [bsky, 0 points, 0 comments]

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