2014/04/16 by Eric A. Standley, Stacey J. Smith, Peter Müller +2 · 1 citation
Chemistry · #Asymmetric Hydrogenation and Catalysis #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods
paper · doi:10.1021/om500156q
openalex publication_date 2014/04/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
High Resolution Image Download MS PowerPoint Slide A series of air-stable nickel complexes of the form L 2 Ni(aryl) X (L = monodentate phosphine, X = Cl, Br) and LNi(aryl)X (L = bis-phosphine) have been synthesized and are presented as a library of precatalysts suitable for a wide variety of nickel-catalyzed transformations. These complexes are easily synthesized from low-cost NiCl 2 ·6H 2 O or NiBr 2 ·3H 2 O and the desired ligand followed by addition of 1 equiv of Grignard reagent. A selection of these complexes were characterized by single-crystal X-ray diffraction, and an analysis of their structural features is provided. A case study of their use as precatalysts for the nickel-catalyzed carbonyl-ene reaction is presented, showing superior reactivity in comparison to reactions using Ni(cod) 2 . Furthermore, as the precatalysts are all stable to air, no glovebox or inert-atmosphere techniques are required to make use of these complexes for nickel-catalyzed reactions.