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Non-invasive imaging-guided preclinical assessments reveal high performance photothermal effect of an Au-solid lipid nanomaterial

2025/01/01 by Chetna Patnaik, B. Pradeep K. Reddy, Anuradha Gupta +8 · 1 voice
Biochemistry, Genetics and Molecular Biology · Engineering · Materials Science · #Extracellular vesicles in disease #Gold and Silver Nanoparticles Synthesis and Applications #Nanoplatforms for cancer theranostics

paper · doi:10.1039/d5nr01472g

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

< 0.0001), while tomographic imaging modalities provided comprehensive insights into the primary debulking efficiency and post-treatment healing process. PTT using Au-SLNs resulted in complete remission of small tumours, but for late-stage tumours, booster dose optimization was required to deliver enhanced survival benefits. These findings underscore the therapeutic potential of Au-SLNs as an effective standalone photothermal agent for treating solid tumours. This study shows that PTT-mediated tumour debulking greatly improves post-treatment life expectancy with no visible distress symptoms, thus paving the way for its future clinical application.

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