A Diagnostic Challenge: Palatal Nodules as the First Sign of IgG4-Related Disease

2025/08/15 by Shuangshuang Wu, Zhimin Yan · 1 voice
Medicine · #IgG4-Related and Inflammatory Diseases #Neuroendocrine Tumor Research Advances #Congenital Ear and Nasal Anomalies

paper · pdf · doi:10.3899/jrheum.2025-0569

openalex publication_date 2025/08/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a systemic, immune-mediated fibroinflammatory disorder characterized by tumor-like organ enlargement, dense lymphoplasmacytic infiltrates, and storiform fibrosis.¹ Early diagnosis is challenging when IgG4-RD presents as isolated palatal gland nodules, a rare and frequently overlooked manifestation of oral involvement.

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