2016/09/19 by Varsha Dalal, Varsha, Dalal, Manveen Kaur +5
Medicine · #610 Medical sciences #Histiocytic Disorders and Treatments #Immunohistochemie #Langerhans cell histiocytosis #Langerhans-Zell-Histiozytose #Medicine #Parvovirus B19 Infection Studies #Tumors and Oncological Cases #immunohistochemistry #oral ulcer #orale Tumoren
paper · doi:10.3205/000238
openalex publication_date 2016/09/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/19
Langerhans cell histiocytosis (LCH) is a relatively rare and unique disease characterized by an abnormal proliferation of immature dendritic cells. It is predominantly seen in children with adults showing less than ten times the incidence compared to childhood. The clinical presentation and organ involvement is highly variable. Oral manifestations generally consist of mucosal ulceration associated with lesions of the underlying bone. Lesions limited to the oral mucosa are rare. We present a case of a 45-year-old male who presented with an ulcer on the hard palate showing histopathologic features of LCH. The present case is a reminder of the possibility of occurrence of this unusual entity in the oral cavity. Appropriate use of immunohistochemistry is advocated to avoid diagnostic pitfalls.