2025/09/03 by Wendy Qiu, Zaid Patel, Benjamin Emert +1 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Histiocytic Disorders and Treatments #Extracellular vesicles in disease #Renal Diseases and Glomerulopathies
paper · pdf · doi:10.5070/rs4.42486
openalex publication_date 2025/09/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
Histiocytoses are rare disorders characterized by abnormal proliferation of histiocytic cells in tissues and organs. They have a broad clinical spectrum and are traditionally categorized as Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (N-LCH), but recent evidence highlights a molecular and clinical overlap between LCH and a type of N-LCH known as Erdheim-Chester disease (ECD). While both disorders have distinct features, up to 20% of ECD patients may present with concurrent LCH lesions. Overlap between LCH and ECD is increasingly recognized, but reports of imaging of this phenomenon are scarce. Here, we present a rare case of directly contiguous LCH and ECD lesions in a 69-year-old woman and discuss the radiologic and histopathologic findings as well as the classification of these findings within the revised histiocytosis system.