Rhodium-catalyzed cycloaddition of bicyclo[1.1.0]butanes with N , N ′-cyclic azomethine imines: en route to fused diaza-3D scaffolds

2025/01/01 by Tianlei Du, Qiujie Qin, Jin Li +6 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic Alkyne Reactions #Cyclopropane Reaction Mechanisms #Fluorine in Organic Chemistry

paper · doi:10.1039/d5qo01147g

openalex publication_date 2025/01/01 · openalex created_date 2025/09/17 · openalex updated_date 2026/07/16

Abstract

The construction of aza-3D frameworks has emerged as a pivotal strategy in drug discovery, owing to their ability to mimic heteroarene bioisosteres.

Discussions

• 👉 𝐑𝐡𝐨𝐝𝐢𝐮𝐦-𝐜𝐚𝐭𝐚𝐥𝐲𝐳𝐞𝐝 𝐜𝐲𝐜𝐥𝐨𝐚𝐝𝐝𝐢𝐭𝐢𝐨𝐧 𝐨𝐟 𝐛𝐢𝐜𝐲𝐜𝐥𝐨[𝟏.𝟏.𝟎]𝐛𝐮𝐭𝐚𝐧𝐞𝐬 𝐰𝐢𝐭𝐡 𝐍,𝐍′-𝐜𝐲𝐜𝐥𝐢𝐜 𝐚𝐳𝐨𝐦𝐞𝐭𝐡𝐢𝐧𝐞 𝐢𝐦𝐢𝐧𝐞𝐬 by Zijun Zhou 𝘦𝘵 𝘢𝘭. Rho [bsky, 0 points, 0 comments]

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