2024/08/27 by Françoise Boismal, S. Peltier, Sophie Ly Ka So +13 · 1 voice
Medicine · Agricultural and Biological Sciences · #Skin Protection and Aging #Telomeres, Telomerase, and Senescence #Biocrusts and Microbial Ecology
paper · pdf · doi:10.18632/aging.206055
openalex publication_date 2024/08/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
<0.05), with a 77% decrease in the number of secreted proteins in aged cells. Proteome comparison between young and aged fibroblasts identified a significant change of 63 proteins in resting condition, and 73 proteins in TGF-β1-stimulated condition, with a 67% increase in the number of proteins in aged fibroblasts. The majority of the differentially-expressed molecules belongs to the cytoskeleton-associated proteins and aging was characterized by an increase in Coronin 1C (CORO1C), and Filamin B (FLNB) expression in fibroblasts together with a decrease in Cofilin (CFL1), and Actin alpha cardiac muscle 1 (ACTC1) detection in aged cells, these proteins being involved in actin-filament polymerization and sharing co-activity in cell motility. Our present data reinforce knowledge about an age-related alteration in the synthesis of major proteins linked to the migratory and contractile functions of dermal human fibroblasts.