Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1980/01/01 by Akira Endo, AKIRA ENDO · 3 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Food Quality and Safety Studies #Natural product bioactivities and synthesis #Plant biochemistry and biosynthesis

paper · doi:10.7164/antibiotics.33.334

crossref issued 1980/01/01 · crossref published 1980/01/01 · crossref published-print 1980/01/01 · openalex publication_date 1980/01/01 · crossref created 2012/02/29 · crossref deposited 2012/02/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23 · crossref indexed 2026/07/31

Citations

• ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.
• Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

Cited by

• The discovery and development of HMG-CoA reductase inhibitors.
• Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells
• Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs