Challenges and discoveries in the total synthesis of complex polyketide natural products

2017/10/25 by Ian Paterson, Nelson Yuen Sum Lam, Nelson Y. S. Lam
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biochemistry #Biology #Biosynthesis #Chemistry #Computational biology #Marine Sponges and Natural Products #Microbial Natural Products and Biosynthesis #Natural (archaeology) #Polyketide #Stereochemistry #Synthetic Organic Chemistry Methods #Total synthesis

paper · doi:10.1038/ja.2017.111

crossref issued 2017/10/25 · crossref published 2017/10/25 · crossref published-online 2017/10/25 · openalex publication_date 2017/10/25 · crossref created 2017/10/25 · crossref published-print 2018/02/01 · crossref deposited 2023/01/01 · openalex created_date 2025/10/10 · crossref indexed 2026/08/01 · openalex updated_date 2026/08/04

Citations

• Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride
• Catalytic effect of nickel(II) chloride and palladium(II) acetate on chromium(II)-mediated coupling reaction of iodo olefins with aldehydes
• A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization
• Highly Selective Synthesis of Z-Unsaturated Esters by Using New Horner−Emmons Reagents, Ethyl (Diarylphosphono)acetates
• Catalytic Asymmetric Dihydroxylation