Mechanistic insights into NOBA hydrolysis by viper venom secreted phospholipase A2

2025/12/06 by Ana Rita Calixto, Roberto Pinto, Maciej Spiegel +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Earth and Planetary Sciences · #Venomous Animal Envenomation and Studies #Marine Invertebrate Physiology and Ecology #Ion channel regulation and function

paper · doi:10.1016/j.biochi.2025.12.003

openalex created_date 2025/12/06 · openalex publication_date 2025/12/06 · openalex updated_date 2026/07/28

Abstract

toxicity, even though it does not account for the equally important membrane-binding component of the toxicity mechanism.

Citations

• A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model
• Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes
• PubChem 2023 update
• UniProt: the Universal Protein Knowledgebase in 2023

Discussions

• 🐍🔥 New paper out! We used QM/MM to investigate the mechanism of Bothrops asper sPLA2, revealing a novel mixed single-water/assisted water pathway. This clarity is vital for advancing anti-venom drug [bsky, 0 points, 0 comments]