Expanding the actinomycetes landscape for phosphonate natural products through genome mining

2025/12/16 by Alina Zimmermann, Shu-Ning Xia, Julia Moschny +9 · 1 voice
Medicine · Chemistry · #Microbial Natural Products and Biosynthesis #Organophosphorus compounds synthesis #Synthetic Organic Chemistry Methods

paper · pdf · doi:10.1039/d5cb00254k

openalex created_date 2025/12/16 · openalex publication_date 2025/12/16 · openalex updated_date 2026/07/18

Abstract

, whereas overexpression of a cluster-situated LuxR-like regulator improved phosphonate production. These findings highlight the P-NP biosynthetic potential of actinomycetes and pave the way for discovering novel bioactive phosphonates.

Citations

• The evolution of genome mining in microbes – a review
• clinker & clustermap.js: automatic generation of gene cluster comparison figures
• antiSMASH 6.0: improving cluster detection and comparison capabilities
• Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide
• Discovery of Antimicrobial Phosphonopeptide Natural Products from Bacillus velezensis by Genome Mining
• antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation
• ModelTest-NG: A New and Scalable Tool for the Selection of DNA and Protein Evolutionary Models
• The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants†

Discussions

• How can #GenomeMining accelerate the discovery of phosphonate #NaturalProduct producers?🦠 New research from @leibniz-dsmz.bsky.social and @unituebingen.bsky.social highlights actinomycetes as a rich [bsky, 0 points, 0 comments]