2023/03/10 by Jing Guo, Lynn Jeanette Savic, Karl H. Hillebrandt +2 · 1 citation
Engineering · Medicine · #Advanced MRI Techniques and Applications #Elasticity and Material Modeling #Ultrasound Imaging and Elastography
paper · doi:10.1097/rli.0000000000000971
openalex publication_date 2023/03/10 · crossref created 2023/03/10 · crossref issued 2023/04/03 · crossref published 2023/04/03 · crossref published-online 2023/04/03 · crossref published-print 2023/08/01 · crossref deposited 2025/08/02 · openalex created_date 2025/10/10 · crossref indexed 2026/08/01 · openalex updated_date 2026/08/02
ABSTRACT: The mechanical traits of cancer include abnormally high solid stress as well as drastic and spatially heterogeneous changes in intrinsic mechanical tissue properties. Whereas solid stress elicits mechanosensory signals promoting tumor progression, mechanical heterogeneity is conducive to cell unjamming and metastatic spread. This reductionist view of tumorigenesis and malignant transformation provides a generalized framework for understanding the physical principles of tumor aggressiveness and harnessing them as novel in vivo imaging markers. Magnetic resonance elastography is an emerging imaging technology for depicting the viscoelastic properties of biological soft tissues and clinically characterizing tumors in terms of their biomechanical properties. This review article presents recent technical developments, basic results, and clinical applications of magnetic resonance elastography in patients with malignant tumors.