2026/01/07 by Timothy D. Schoch, Jeffrey M. Lipshultz · 1 voice
paper · doi:10.1002/9780470842898.rn02664
openalex publication_date 2026/01/07 · openalex created_date 2026/01/08 · openalex updated_date 2026/07/14
chemical structure image [1849‐54‐3] C 6 H 5 NO 2 (MW 123.11) InChI = 1S/C6H5NO2/c8‐4‐5‐1‐2‐7‐3‐6(5)9/h1‐4,9H InChIKey = NVLPDIRQWJSXLZ‐UHFFFAOYSA‐N (used as a synthon for certain heterocycles, a ligand precursor, and a mimic of pyridoxal 5′‐phosphate or PLP) Alternative Name(s): 3‐hydroxyisonicotinaldehyde , 3‐hydroxy‐4‐formylpyridine, HINA . Physical Data: mp 132–133 °C. Solubility: soluble in water and most organic solvents. Form Supplied in: pale yellow to brown solid, commercially available. Preparative Methods: sequential Boekelheide reactions and hydrolyses of 4‐picoline N‐oxide followed by oxidation of the corresponding alcohol with MnO 2 . 1,2 image Purification: recrystallization from hexane and/or sublimation.