2020/12/24 by Dustin Bornemann, Fabian Brüning, Niccolò Bartalucci +2 · 1 citation
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Alkyl #Chemical Synthesis and Reactions #Chemistry #Chloride #Chlorine #Fluorine in Organic Chemistry #Halogen #Heteroatom #Medicinal chemistry #Organic chemistry #Oxalyl chloride #Sulfur-Based Synthesis Techniques #Trichloroisocyanuric acid
paper · doi:10.1002/hlca.202000218
openalex publication_date 2020/12/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Abstract A mild, oxidative fluorination approach to a variety of fluorinated phosphorus compounds using trichloroisocyanuric acid (TCICA) and KF was developed as a complement to a recent study on deoxygenative fluorination using oxalyl chloride. Herein, the syntheses of several fluorinated organophosphorus compounds are reported, and both TCICA/KF and oxalyl chloride/KF conditions are compared and contrasted throughout. Initial investigations of the method on other group 15 heteroatoms ( i. e ., As, Sb, and Bi) are also reported, with varied success. This work notably extends the known TCICA/KF reactivity series to another group of elements beyond previously studied chalcogens (S, Se, and Te) and halogens (iodine) and expands the utility of the previously reported oxalyl chloride/KF method.