One‐Pot Four‐Component Synthesis of Thieno[2,3‐d]pyrimidin‐4‐amines via Sequential Gewald/Cyclocondensation Reactions

2015/08/01 by Mehdi Adib, Helya Janatian Ghazvini, Helia Janatian Ghazvini +4 · 1 citation
Chemistry · #Catalysis #Chemistry #Claus process #Combinatorial chemistry #Component (thermodynamics) #Condensation #Hydrogen sulfide #Malononitrile #Multicomponent Synthesis of Heterocycles #Organic chemistry #Quinazolinone synthesis and applications #Reaction conditions #Solvent #Sulfur #Synthesis and biological activity #Thiophene

paper · doi:10.1002/hlca.201500008

openalex publication_date 2015/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

Abstract A one‐pot four‐component synthesis of thieno[2,3‐ d ]pyrimidin‐4‐amines via sequential Gewald /cyclocondensation reactions is described. 2‐Aminothiophene‐3‐carbonitriles obtained from the Gewald reaction between cyclic ketones, malononitrile, and sulfur underwent a condensationcyclization reaction with benzonitriles under solvent‐free conditions to afford the title compounds in excellent yields.

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• Green methodologies for the synthesis of 2-aminothiophene. [europepmc]

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