Three-Component Reaction between Isocyanides, Aliphatic Amines and Elemental Sulfur: Preparation of Thioureas under Mild Conditions with Complete Atom Economy

2014/10/31 by Thanh Nguyen, Thanh Bình Nguyễn, Ali Al-Mourabit +2
Chemistry · #Sulfur-Based Synthesis Techniques #Chemical Synthesis and Reactions #Multicomponent Synthesis of Heterocycles

paper · doi:10.1055/s-0034-1379327

Abstract

The reaction of isocyanides with aliphatic amines in the presence of elemental sulfur was found to proceed efficiently at, or near, room temperature to produce thioureas in excellent yields and with complete atom economy.

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