Reports of My Demise Have Been Greatly Exaggerated

2026/02/01 by Andrew S. Haynes, Kira E. Frappa, Matthew Miller · 1 voice
Medicine · #Antimicrobial Resistance in Staphylococcus #Clostridium difficile and Clostridium perfringens research #Antifungal resistance and susceptibility

paper · doi:10.1093/jpids/piag027

openalex publication_date 2026/02/01 · openalex created_date 2026/04/03 · openalex updated_date 2026/07/29

Abstract

Lay Summary In a satirical response, vancomycin defends its modern relevance by highlighting dosing by area under the curve (AUC), predictable pharmacokinetics, durability against resistance, and established clinical scenarios where it remains essential, while challenging assumptions about linezolid’s convenience, toxicity profile, and emerging resistance concerns.

Citations

• The emerging problem of linezolid-resistant Staphylococcus

Discussions

• Reports of My Demise Have Been Greatly Exaggerated doi.org/10.1093/jpid... [bsky, 0 points, 1 comments]

Related

• Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists
• Emergence of Daptomycin-Resistant VRE: Experience of a Single Institution
• Vancomycin Monitoring in Kidney Transplants Within 1 Year
• Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria
• Treatment of MRSA pneumonia: Clinical and economic comparison of linezolid vs. vancomycin – a retrospective analysis of medical charts and re-imbursement data of real-life patient populations