Emergence of Daptomycin-Resistant VRE: Experience of a Single Institution

2011/04/01 by Mini Kamboj, Nina Cohen, Kathleen Gilhuley +3

paper · doi:10.1086/659152

Abstract

Recent surveillance from US hospitals shows that more than 99.5% of vancomycin-resistant enterococci (VRE) isolates remain susceptible to daptomycin. This report describes emergence of daptomycin-resistant VRE at a major cancer center. The percentage of patients with daptomycin-resistant VRE bacteremia increased from 3.4% in 2007 to 15.2% in 2009 ( P = .03). Without susceptibility data, empiric daptomycin therapy for VRE infections should be used with caution.

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