2026/01/01 by Robert Dörrenhaus, Andre Zenz, Stephanie Kath-Schorr · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #DNA and Nucleic Acid Chemistry #Carbohydrate Chemistry and Synthesis #HIV/AIDS drug development and treatment
paper · pdf · doi:10.1039/d6cb00078a
openalex publication_date 2026/01/01 · openalex created_date 2026/03/27 · openalex updated_date 2026/06/11
Advances in nucleic acid chemistry have driven the development of a wide variety of artificial nucleobases. The synthesis of the glycosidic bond towards nucleosides still remains a major challenge in nucleic acid chemistry, particularly for C-glycosidic DNA nucleosides. This review highlights the Heck reaction as a central and versatile strategy for constructing diverse C-glycosidic DNA analogues. It discusses the underlying reaction mechanism, commonly employed catalyst and ligand systems and the scope of tolerated substituents. In addition, the review summarizes the subsequent applications of these artificial nucleobases with a particular emphasis on fluorescent nucleobase analogues.