Asymmetric synthesis of propargylic alcohols using bifunctional glucose dehydrogenases

2026/01/01 by Rohit Kumar, Simran Bhatia, Samantha J. Tambrini +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · #Enzyme Catalysis and Immobilization #Cyclopropane Reaction Mechanisms #Synthetic Organic Chemistry Methods

paper · doi:10.1039/d5cc07322g

openalex publication_date 2026/01/01 · openalex created_date 2026/04/09 · openalex updated_date 2026/07/16

Abstract

Two bifunctional glucose dehydrogenases enable asymmetric reduction of propargylic ketones, affording chiral propargylic alcohols in excellent yields, with gram-scale feasibility.

Discussions

• New research from WSU EACPHS reports a bifunctional enzyme approach for efficient, enantioselective synthesis of chiral propargylic alcohols with scalable potential. doi.org/10.1039/d5cc... [bsky, 0 points, 0 comments]

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