Isotretinoin’s transcriptomics: Much more than mTORC1 inhibition

2026/03/10 by Bodo C. Melnik · 1 voice
Biochemistry, Genetics and Molecular Biology · #Component (thermodynamics) #Context (archaeology) #Nutrition, Genetics, and Disease #PI3K/AKT/mTOR signaling in cancer #Ubiquitin and proteasome pathways #Work (physics)

paper · pdf · doi:10.1016/j.jid.2026.02.002

openalex publication_date 2026/03/10 · crossref created 2026/03/10 · openalex created_date 2026/03/11 · crossref deposited 2026/06/23 · crossref indexed 2026/06/23 · crossref issued 2026/07/01 · crossref published 2026/07/01 · crossref published-print 2026/07/01 · openalex updated_date 2026/07/28

Citations

• Connectivity mapping with isotretinoin’s transcriptomic signature identifies alternative therapeutics for severe acne

Discussions

• A commentary by Bodo Melnik, "Isotretinoin’s Transcriptomics: Much More than mTORC1 Inhibition" https://doi.org/10.1016/j.jid.2026.02.002 linked article: https://doi.org/10.1016/j.jid.2025.11.025 #JID [bsky, 0 points, 0 comments]