Plasma microbial cell-free DNA sequencing for detection of Coxiella burnetii aortic endograft infection with vertebral osteomyelitis

2026/01/01 by Ashita Jain, Sarwat Khalil, M. Rizwan Sohail +4 · 1 voice
Immunology and Microbiology · Medicine · #Vector-borne infectious diseases #Rabies epidemiology and control #Infectious Aortic and Vascular Conditions

paper · pdf · doi:10.1017/ash.2026.10782

openalex publication_date 2026/01/01 · openalex created_date 2026/07/06 · openalex updated_date 2026/07/12

Abstract

Abstract Chronic Q fever can present as culture-negative aortic endograft infection with osteomyelitis. Plasma microbial cell-free DNA sequencing unexpectedly detected Coxiella burnetii before serology, prompting exposure reassessment and targeted therapy. Later operative cultures grew Eikenella corrodens , underscoring the need to pair molecular results with serology and source-control microbiology.

Discussions

• Plasma microbial cell-free DNA detected C. burnetii in a culture-negative aortic endograft infection with vertebral osteomyelitis, supporting targeted therapy and surgical planning. This case highligh [bsky, 0 points, 0 comments]

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