Mindful diagnostics in culture-negative endocarditis: early noninvasive diagnosis of Tropheryma whipplei by plasma microbial cell-free DNA

2026/01/01 by Ashita Jain, Sarwat Khalil, Muhammad R. Sohail +6 · 1 voice
Medicine · #Infectious Diseases and Tuberculosis #Otitis Media and Relapsing Polychondritis #Whipple's Disease and Interleukins

paper · pdf · doi:10.1017/ash.2026.10416

openalex publication_date 2026/01/01 · openalex created_date 2026/06/17 · openalex updated_date 2026/07/28

Abstract

was identified by plasma microbial cell-free DNA sequencing within 4 days in severe culture-negative endocarditis after antibiotics had already been started. The result supported earlier diagnostic clarification and antimicrobial de-escalation before valve pathology was available, illustrating a practical diagnostic-stewardship role for noninvasive sequencing in high-acuity endocarditis.

Discussions

• Plasma microbial cell-free DNA sequencing enabled rapid, noninvasive diagnosis of Tropheryma whipplei culture-negative endocarditis, allowing earlier targeted therapy before surgical pathology. doi.or [bsky, 1 points, 0 comments]

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