Transformation of 5-acylated N -fluoroalkyl-1,2,3-triazoles to trifluoromethylated ring-fused isoquinolines, 1,3-oxazines, and 1,3-oxazin-6-ones via ketenimines

2024/01/01 by Lukáš Janecký, Blanka Klepetářová, Petr Beier · 1 voice
Pharmacology, Toxicology and Pharmaceutics · Chemistry · #Fluorine in Organic Chemistry #Cyclopropane Reaction Mechanisms #Synthesis and Biological Evaluation

paper · pdf · doi:10.1039/d4ra04794j

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14

Abstract

-pentafluoroethyl-substituted 1,2,3-triazoles is presented. A thermal ring opening of the starting triazoles, followed by a 1,2-acyl shift formed reactive ketenimines which cyclized after a rearrangement in a substrate-specific manner to provide new trifluoromethylated heterocyclic products.

Citations

• Current Contributions of Organofluorine Compounds to the Agrochemical Industry

Discussions

• #research Transformation of 5-acylated N-fluoroalkyl-1,2,3-triazoles to trifluoromethylated ring-fused isoquinolines, 1,3-oxazines, and 1,3-oxazin-6-ones via ketenimines (Beier) - RSCAdvances: doi. [bsky, 1 points, 0 comments]

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