Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

2024/09/13 by Jeremy Baldwin, Christoph Heuser, Tanmoy Saha +27 · 1 voice · 3 citations
Engineering · Medicine · #Graphene and Nanomaterials Applications #CAR-T cell therapy research #Nanoplatforms for cancer theranostics

paper · doi:10.1016/j.cell.2024.08.029

openalex publication_date 2024/09/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

T cells mediated superior antitumor responses, prolonging animal survival. These findings establish intercellular mitochondrial transfer as a prototype of organelle medicine, opening avenues to next-generation cell therapies.

Citations

• Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
• Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
• Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization

Cited by

• Nanoparticle shape is the game-changer for blood–brain barrier crossing and delivery through tunneling nanotubes among glioblastoma cells
• Overcoming resistance to anti-PD-L1 immunotherapy: mechanisms, combination strategies, and future directions
• Regulators of CD8+ T cell exhaustion

Discussions

• #SharingIsCaring #EveryCellIsAnImmuneCell #ImmunometabolismPower! Baldwin, Gattinoni, Sengupta &co show @ Cell that bone marrow stromal cells transfer #mitochondria to CD8 T cells supercharging them [bsky, 1 points, 0 comments]

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