Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

2016/06/01 by Michael D. Buck, Michael D. Buck, David O’Sullivan +29 · 1 voice · 19 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Cancer, Hypoxia, and Metabolism #Immune cells in cancer #Mitochondrial Function and Pathology

paper · pdf · doi:10.1016/j.cell.2016.05.035

crossref issued 2016/06/01 · crossref published 2016/06/01 · crossref published-print 2016/06/01 · openalex publication_date 2016/06/01 · crossref created 2016/06/11 · crossref deposited 2022/11/16 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31

Citations

• Mitochondrial bioenergetics and structural network organization
• T cell metabolism drives immunity

Cited by

• The cancer metabolic reprogramming and immune response
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• Photocatalytic labelling-enabled subcellular-resolved RNA profiling and synchronous multi-omics investigation
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• Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
• Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
• Metabolic drives affecting Th17/Treg gene expression changes and differentiation: impact on immune‐microenvironment regulation
• Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion
• Inflammation- and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cancer
• Palmitate-induced mitochondrial damage restricts histone acetylation in CD8 ⁺ T cells to impair anti-tumor immunity
• The generation of senescent-like CD4+ EMRA T cells in T2D and their contribution to poor COVID-19 vaccine responses
• Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism
• Lipopolysaccharide‐induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo
• PIM kinase control of CD8 T cell protein synthesis and cell trafficking
• IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
• Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
• Single-cell transcriptomic analysis reveals RNA-binding protein dysregulation in immune checkpoint inhibitor–induced colitis
• Single-cell capture of on-ART SIV transcription reveals TGF-β–mediated metabolic control of viral latency
• Triacylglycerol synthesis enhances macrophage inflammatory function

Discussions

• Effector CD8 T cells have punctate mitochondria with loose cristae, favoring glycolysis and memory T cells elongated mitochondria with tight cristae, favoring OxPhos. Pharmacologic remodeling of mito [bsky, 5 points, 0 comments]