At the crossroads of biology and electronics

2025/01/09 by Gokberk Unal, Martin Fussenegger · 1 voice
Engineering · Neuroscience · #Molecular Communication and Nanonetworks #Neuroscience and Neural Engineering #Photoreceptor and optogenetics research

paper · doi:10.1016/j.copbio.2024.103249

openalex publication_date 2025/01/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

All cells are innately equipped with systems to detect and respond to electrical inputs in the form of reactive oxygen species, redox signaling, or membrane depolarization through ion exchange. Electrogenetics aims to leverage these cellular systems to create interfaces between biology and electronics, in order to achieve levels of precision in spatiotemporal control of gene and protein expression that are not possible with chemo-, opto-, or thermogenetics. In this review, we discuss the impact, challenges, and prospects of electrogenetics in the context of recent cutting-edge applications.

Citations

• Highly accurate protein structure prediction with AlphaFold
• Programming mammalian cell behaviors by physical cues

Discussions

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