2024/08/23 by Jinbo Huang, Martin Fussenegger · 1 voice · 2 citations
Neuroscience · Engineering · #Neuroscience and Neural Engineering #Neural dynamics and brain function #3D Printing in Biomedical Research
paper · doi:10.1016/j.tibtech.2024.07.014
openalex publication_date 2024/08/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/16
In recent decades, the field of synthetic biology has witnessed remarkable progress, driving advances in both research and practical applications. One pivotal area of development involves the design of transgene switches capable of precisely regulating specified outputs and controlling cell behaviors in response to physical cues, which encompass light, magnetic fields, temperature, mechanical forces, ultrasound, and electricity. In this review, we delve into the cutting-edge progress made in the field of physically controlled protein expression in engineered mammalian cells, exploring the diverse genetic tools and synthetic strategies available for engineering targeting cells to sense these physical cues and generate the desired outputs accordingly. We discuss the precision and efficiency limitations inherent in these tools, while also highlighting their immense potential for therapeutic applications.