Stereoselective synthesis of atropisomeric amides enabled by intramolecular acyl transfer

2025/01/01 by Jack M. Wootton, Natalie J. Roper, Catrin E. Morris +9 · 1 voice
Chemistry · #Axial and Atropisomeric Chirality Synthesis #Chemical synthesis and alkaloids #Molecular spectroscopy and chirality

paper · pdf · doi:10.1039/d4sc05760k

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/02

Abstract

initial fast acylation of the Lewis basic group, followed by rate-determining acyl transfer, which also enables control over the atropisomer formed.

Citations

• Recent Advances in Catalytic Asymmetric Construction of Atropisomers
• Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis

Discussions

• I think the full DOI for this should be doi.org/10.1039/D4SC... 🙂 [bsky, 1 points, 1 comments]

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