2025/06/15 by Rui Han, Jun Zhang, Hao Huang +8 · 1 voice
Medicine · Neuroscience · #Circadian rhythm and melatonin #Coffee research and impacts #Neurobiology and Insect Physiology Research
paper · doi:10.1111/eth.70002
openalex publication_date 2025/06/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/15
ABSTRACT The effects of sleep deprivation on organisms have become an important research topic. Prolonged sleep deprivation not only affects locomotion and cognition in humans but also has a significant negative effect on the lifespan of organisms. This study investigated the effects of weekly continuous light exposure (16, 20, or 24 h) as a method of sleep deprivation on the behavior of Drosophila melanogaster and evaluated the potential recovery effects of caffeine and other components in coffee on fruit flies. The results revealed that weekly sleep deprivation reduced the activity level and short‐term spatial memory of fruit flies. In contrast, moderate coffee intake (0.1 g/L caffeine content) not only had positive effects on nonsleep‐deprived fruit flies but also reduced the negative effects caused by sleep deprivation. Our study assessed the short‐term and long‐term effects of coffee during the sleep deprivation process and examined the relationships between these effects and the aging of fruit flies. Through this research, we aim to gain a deeper understanding of the mechanisms by which coffee affects sleep deprivation and provide new insights and references for future studies.