2026/02/13 by Yu-Chien Hung, Mehran Akhtar, Nithish Sattoju +7 · 1 voice
Neuroscience · #Circadian rhythm and melatonin #Neurobiology and Insect Physiology Research #Sleep and Wakefulness Research
paper · doi:10.1016/j.nbscr.2026.100146
openalex publication_date 2026/02/13 · openalex created_date 2026/02/14 · openalex updated_date 2026/07/23
The daily sleep-wake cycle is a conserved behaviour defined by locomotion quiescence and enhanced responsive threshold to sensory stimuli. Both the circadian clock and sleep-homeostasis determine the daily sleep profile. Environmental light is a major sensory input and also regulates circadian clock and the balance between sleep and wakefulness. In Drosophila , the cellular mechanism and neural circuitry underlying light-mediated circadian synchronization are well-established, yet the direct relationship between light/visual input and sleep remains unclear. To address this knowledge gap, we measured sleep behaviour in Drosophila with mutations in genes involved in phototransduction and downstream neural transmission. We observed consistent day sleep fragmentation in flies with mutations in multiple phototransduction components. We also found that mutation that led to hyperpolarised Drosophila photoreceptors resulted in shorter day sleep. We found a severe reduction in locomotor speed in several visual mutants during normal waking time preventing assessment of their sleep-linked immobility. Taken together, our rigorous quantification of sleep in phototransduction genetic mutants reveals the key role of visual input in promoting sleep. • Phototransduction is required for promoting day sleep in Drosophila • Compound eye photoreceptors mediate divergent neural outputs to regulate sleep • Measuring waking activity is essential to mitigating sleep overestimation.