Transforming docetaxel delivery: lung-targeted polyphosphazene nanoparticles with enhanced safety profile

2025/01/01 by N. Sanoj Rejinold, Geun‐woo Jin, Jieun Oh +2 · 1 voice
Chemistry · #Synthesis and biological activity #Multicomponent Synthesis of Heterocycles #Microwave-Assisted Synthesis and Applications

paper · pdf · doi:10.1039/d5nr02201k

openalex publication_date 2025/01/01 · openalex created_date 2025/07/25 · openalex updated_date 2026/07/28

Abstract

metabolic profiling revealed a distinct biodegradation and clearance mechanism, with minimal generation of inactive or toxic metabolites. These results highlight the potential of PTX as a safe and effective drug delivery platform that combines enhanced therapeutic performance with reduced systemic burden, supporting its future clinical translation in cancer chemotherapy.

Citations

• Cancer statistics, 2025

Discussions

• In the inside front cover article for Nanoscale Issue 37, Jin-Ho Choy et al demonstrate that polytaxel (PTX) achieves robust anti-tumour efficacy both in vitro and in vivo, while markedly reducing sys [bsky, 1 points, 0 comments]

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