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Single-crystal structure of the spicy capsaicin

2025/03/07 by Matic Lozinšek · 1 voice · 1 citation
Medicine · Chemistry · Agricultural and Biological Sciences · #Phytochemicals and Antioxidant Activities #Free Radicals and Antioxidants #Ziziphus Jujuba Studies and Applications

paper · pdf · doi:10.1107/s2053229625001706

Abstract

), or trans-8-methyl-N-vanillylnon-6-enamide, the natural product responsible for the spiciness of chilli peppers, was determined using low-temperature single-crystal X-ray diffraction. The reported crystal structure is in good agreement with previous determinations based on powder X-ray diffraction data. The localization and free refinement of all H atoms revealed that each capsaicin molecule is hydrogen bonded to four other molecules, with the O-H and N-H groups acting as hydrogen-bond donors, and the C=O group serving as a bifurcated hydrogen-bond acceptor.

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