2026/01/01 by Saurav Joshi, Dillon Rickertsen, Emma George +2 · 1 voice
Chemistry · #Radical Photochemical Reactions #Catalytic C–H Functionalization Methods #Catalytic Cross-Coupling Reactions
paper · doi:10.1039/d6qo00525j
openalex publication_date 2026/01/01 · openalex created_date 2026/05/19 · openalex updated_date 2026/07/27
A Lewis acid-activated acridine photocatalytic platform is reported that enables intramolecular Giese-type cyclizations of α-amidyl radicals under mild photochemical conditions. This approach addresses longstanding challenges associated with α-amidyl radical reactivity and provides direct access to bicyclic and polycyclic nitrogen frameworks, including izidinones, izidines, and indoloquinolizidines. The method displays broad substrate scope and enables the efficient construction of annulated azacycles that are difficult to access using existing radical or ionic strategies. The synthetic utility of the protocol is demonstrated through formal syntheses of the indoloquinolizidine alkaloids (±)-eburnaminol and (±)-larutensine, underscoring its value for the rapid assembly of a structurally complex, medicinally relevant polycyclic ring system.