Selective defluorinative [4 + 3] annulation to access fluorinated oxazepines and thiazepines

2025/12/09 by Farah Firdous, Sohail Akbar, Ping Jiang +2 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Fluorine in Organic Chemistry

paper · doi:10.1039/d5qo01324k

openalex created_date 2025/12/09 · openalex publication_date 2025/12/09 · openalex updated_date 2026/06/11

Abstract

We present a powerful, metal-free annulation that directly transforms α-CF 3 -styrenes into valuable fluorinated seven-membered heterocycles, including thiazepine and oxazepine frameworks.

Citations

• Current Contributions of Organofluorine Compounds to the Agrochemical Industry
• New Opportunities to Access Fluorinated Molecules Using Organophotoredox Catalysis via C(sp³)–F Bond Cleavage

Discussions

• Recent research by Keyume Ablajan's team. #XinjiangUniversity Authors present a novel, practical, and mild base-mediated SN2′/SNV and ipso-/γ-selective defluorinative annulation of heteroaryl-based b [bsky, 1 points, 0 comments]

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