Diagnosis of histoplasmosis by next-generation sequencing of microbial cell-free DNA in Texas

2026/01/01 by Fernando H. Centeno, Todd Lasco, Mayar Al Mohajer · 1 voice
Medicine · #Antifungal resistance and susceptibility #Fungal Infections and Studies #Nail Diseases and Treatments

paper · doi:10.1017/ash.2026.10429

openalex publication_date 2026/01/01 · openalex created_date 2026/06/02 · openalex updated_date 2026/06/07

Abstract

We examine the impact of microbial cell-free DNA (mcfDNA) NGS for the diagnosis of Histoplasma capsulatuim in a quaternary referral center in Texas. Of eight included patients, five had a change in their antifungal coverage after mcfDNA NGS results with faster turnaround times than antigen testing and cultures.

Discussions

• Case series examines patients diagnosed with Histoplasma infections by microbial cell-free DNA next-generation sequencing. In most cases, next-generation sequencing was the first positive result. doi. [bsky, 1 points, 0 comments]

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