2019/10/21 by Daping Yang, Yingying Xing, Xinyang Song +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Health Professions · Medicine · #Clostridium difficile and Clostridium perfringens research #Gut microbiota and health #Health, psychology, and well-being
paper · pdf · doi:10.1111/imm.13139
openalex publication_date 2019/10/21 · crossref created 2019/10/21 · crossref issued 2019/11/11 · crossref published 2019/11/11 · crossref published-online 2019/11/11 · crossref published-print 2020/02/01 · crossref deposited 2023/09/07 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/30
Host-microbiota interaction plays fundamental roles in the homeostasis of mucosal immunity. Dysbiosis of intestinal microbiota has been demonstrated to participate in various immune responses and many multifactorial diseases. Study of intestinal microbiota has moved beyond the consequences of dysbiosis to the causal microbiota associated with diseases. However, studies of pulmonary microbiota and its dysbiosis are still in their infancy. Improvement of culture-dependent and -independent techniques has facilitated our understanding of lung microbiota that not only exists in healthy lung tissue but also exerts great impact on immune responses under both physiological and pathological conditions. In this review, we summarize recent progresses of lung microbiota dysbiosis and its impact on the local immune system that determines the balance of tolerance and inflammation. We discuss the causal roles of pulmonary dysbiosis under disease settings, and propose that the interaction between lung microbiota and host is critical for establishing the immune homeostasis in lung.