Protein Neddylation Beyond Tumor Cells is a Vital Modulator of Anticancer Immunity

2026/02/01 by Mengna Xu, Weixiao Liu, Fan Liu +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Peptidase Inhibition and Analysis #Protein Degradation and Inhibitors #Ubiquitin and proteasome pathways

paper · doi:10.1007/s43657-025-00233-w

crossref issued 2026/02/01 · crossref published 2026/02/01 · crossref published-print 2026/02/01 · openalex publication_date 2026/02/01 · crossref published-online 2026/02/06 · crossref created 2026/02/06 · openalex created_date 2026/02/07 · crossref deposited 2026/06/01 · crossref indexed 2026/06/01 · openalex updated_date 2026/07/29

Citations

• Metabolic reprogramming and cancer progression
• Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis
• Macrophage Polarization

Discussions

• Key Insights: ✅ Neddylation = ubiquitin-like modification via NAE → E2 → E3 cascade ✅ Primary substrates: Cullin-RING E3 ligases (regulate cell cycle, apoptosis, metabolism) [bsky, 1 points, 1 comments]