Macrophage Polarization

2016/11/04 by Peter J. Murray · 16 citations
Immunology and Microbiology · Neuroscience · #Immune cells in cancer #Neuroinflammation and Neurodegeneration Mechanisms #Phagocytosis and Immune Regulation

paper · doi:10.1146/annurev-physiol-022516-034339

Abstract

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment. Three broad pathways control polarization: epigenetic and cell survival pathways that prolong or shorten macrophage development and viability, the tissue microenvironment, and extrinsic factors, such as microbial products and cytokines released in inflammation. A plethora of advances have provided a framework for rationally purifying, describing, and manipulating macrophage polarization. Here, I assess the current state of knowledge about macrophage polarization and enumerate the major questions about how activated macrophages regulate the physiology of normal and damaged tissues.

Citations

• Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice
• Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair

Cited by

• Estrogen Receptor Signaling in the Immune System
• Fisetin-mediated MYC restoration improves age-associated decline in macrophage function
• Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling
• Tumor-Associated Macrophages: Recent Insights and Therapies
• Tricarboxylic acid cycle metabolites: new players in macrophage
• The inflammatory speech of fibroblasts
• Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
• Protein Neddylation Beyond Tumor Cells is a Vital Modulator of Anticancer Immunity
• Effect of clinically relevant iron oxide nanoparticles on macrophage polarization, tumor growth and tumor microenvironment modulation
• The Role of Macrophages in Cancer: From Basic Research to Clinical Applications
• High CD163+CD206+ macrophage infiltration in the bone marrow microenvironment of newly diagnosed multiple myeloma patients
• SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques
• Carboxylesterase 1 contributes to the human macrophage alternative activation response to Th2 cytokine interleukin-4
• Lipid Metabolism in Regulation of Macrophage Functions
• Single-Injection Multi-Omics Analysis by Direct Infusion Mass Spectrometry
• Long non-coding RNA MALAT1 promotes angiogenesis and immunosuppressive properties of HCC cells by sponging miR-140

Related

• The Endocardium
• Obstacles and opportunities for understanding macrophage polarization
• Macrophage plasticity, polarization, and function in health and disease
• Regulation of Internal Body Temperature
• Macrophage Polarization in Bacterial Infections