RUSHing back: Kinetic analysis of adaptor protein complex-1 (AP-1)–mediated retrograde traffic

2024/06/18 by Mara C. Duncan · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Cellular transport and secretion #Endoplasmic Reticulum Stress and Disease #Pancreatic function and diabetes

paper · pdf · doi:10.1083/jcb.202406100

openalex publication_date 2024/06/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Numerous biomedically important cargoes depend on adaptor protein complex-1 (AP-1) for their localization. However, controversy surrounds whether AP-1 mediates traffic from or to the Golgi. Robinson et al. (https://www.doi.org/10.1083/jcb.202310071) present compelling evidence that AP-1 mediates recycling to the Golgi.

Discussions

• I got to write a highlight of the latest work from Scottie Robinson, one of my scientific heroes. She and her team use cutting-edge technologies to finally establish its role in retrieval from the end [bsky, 2 points, 1 comments]

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