2015/07/15 by Shiuan Wang, Hugo J. Bellen · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Cellular transport and secretion #Photoreceptor and optogenetics research #Retinal Development and Disorders
paper · doi:10.1242/dev.123737
openalex publication_date 2015/07/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular mechanisms of retromer-mediated protein trafficking, highlighting key examples of retromer function in vivo.