2025/02/18 by Martha Carnalla, Carlos Gaspar-Castillo, Jisela Dimas-González +8 · 1 voice
Immunology and Microbiology · Mathematics · Medicine · #COVID-19 epidemiological studies #Immune responses and vaccinations #Virology and Viral Diseases
paper · doi:10.1016/j.vaccine.2025.126886
openalex publication_date 2025/02/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
BACKGROUND: Measles is a highly contagious, potentially life-threatening viral disease targeted for global elimination. Deficiencies in vaccination programs and vaccine-induced immunity waning may favor re-emergence. In 2020, Mexico experienced an outbreak, mainly affecting adults in urban areas. METHODS: To estimate vaccination-induced serostatus, we used a probabilistic population-based sample of individuals from the ENSANUT survey in 2022. Seroprevalence was estimated by plaque reduction neutralization test (PRNT) and anti-measles IgG ELISA. RESULTS: Seroprevalence was 82.4 % (95 %CI 79.6, 85.0 %) by PRNT and 61.1 % (95 %CI 58.6, 63.7 %) by ELISA. The 20-29 years of age group showed the lowest PRNT seroprevalence (63.6 %), followed by the 30-39 group (71.8 %) and 40-49 (77.7 %). DISCUSSION: Low seroprevalence in young adults suggests possible low coverage of the second dose and/or waning immunity in absence of viral circulation in the 1989-2008 birth cohorts. In case of imported introduction of measles cases, susceptibility in young adults and adults could facilitate an outbreak.