tRNA modifications tune m6A-dependent mRNA decay

2025/04/30 by Bastian Linder, Puneet Sharma, Jie Wu +10 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · #RNA modifications and cancer #RNA and protein synthesis mechanisms #Cancer-related gene regulation

paper · doi:10.1016/j.cell.2025.04.013

openalex publication_date 2025/04/30 · openalex created_date 2025/05/02 · openalex updated_date 2026/07/22

Abstract

U-is associated with more aggressive tumors and poor prognosis. Overall, this pan-epitranscriptomic interaction represents a novel mechanism of post-transcriptional gene regulation with implications for human health.

Citations

• Codon Optimality Is a Major Determinant of mRNA Stability
• Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
• Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
• The ribotoxic stress response drives UV-mediated cell death

Cited by

• Modifying gene expression through passive forces
• Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance

Discussions

• m6A marks mRNAs for decay—but this paper reveals the twist: tRNA mods like mcm5s2U can rescue them by improving codon decoding. A pan-epitranscriptomic balancing act with major implications for cancer [bsky, 2 points, 0 comments]

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