2026/01/01 by Anwuli Endurance Odieka, Adebola O. Oyedeji · 1 voice
Medicine · Pharmacology, Toxicology and Pharmaceutics · Biochemistry, Genetics and Molecular Biology · #Cannabis and Cannabinoid Research #Forensic Toxicology and Drug Analysis #Pharmacological Receptor Mechanisms and Effects
paper · doi:10.1515/chem-2025-0217
openalex publication_date 2026/01/01 · openalex created_date 2026/07/11 · openalex updated_date 2026/07/16
Abstract Cannabinoids and cannabinoid-like substances, traditionally linked to Cannabis sativa , are now being identified in a diverse range of natural sources, including non-cannabis plants, fungi, microorganisms, and marine organisms. This review explores the variety of cannabinoids and cannabinoid-like compounds, as well as their interactions with the endocannabinoid system. The objective is to thoroughly investigate these compounds and emphasize how different natural sources influence and/or modulate the endocannabinoid system, which has significant implications for therapeutic advancements. By examining the chemical structures, biological functions, and therapeutic potential of these compounds, we can greatly enhance the pharmacognostic dimensions of cannabinoid research. This approach may also uncover new bioactive compounds that could be utilized as precursors for drug development and therapeutic progress extending beyond those derived from cannabis.